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A randomized phase 2 trial assessed the effects of high-dose oral vitamin A on graft-versus-host disease (GVHD) in 80 children and young adults undergoing hematopoietic stem cell transplantation. The trial found that vitamin A reduced the incidence of chronic GVHD and acute gastrointestinal GVHD compared to placebo, with minimal toxicity observed. Overall, vitamin A is suggested as a low-cost and effective intervention to lower GVHD incidence in pre-HSCT patients.

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666gc2b4f6
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