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Alterations by Centrally Acting Drugs of the Suppression of Self-stimulation Behavior in the Rat by Tetrabenazine, Physostigmine, Chlorpromazine and Pentobarbital by M. E. Olds is a Neuroscience article available to read on EtoBox.

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The effects of pre-treatmcnt (32 rain) with &hetamine (2 mg/kg), scopolamine (0.5 mg/kg), and chlordiazepoxide (5 mg/kg) were studied on the suppression of self-stimulation behavior in the male albino rat by central depressants. The antagonism of each compound was determined against the suppressant action of tetrabenazine (2 mg/kg), physostigmine (0.1 mg/kg), chlorpromazine (2.5 mg/kg) and pentobarbital sodium (10 mg/kg). Against the suppression produced by tetrabenazine, only d-amphetamine gave partial protection throughout the test. Scopolamine and chlordiazepoxide had a transient delaying action. Against the suppressant effect of chlorpromazine, protec. tion was given by d-amphetamine, scopolamine and chlordiazepoxide. Against physostigmine, scopolamine gave full protection, d-amphetamine partial protection, and chlordiazepoxide was without effect. Against the effect of pentobarbital on self-stimulation behavior, there was no protection by &hetamine and scopolamine when the animal showed motor deficits, and a stimulant action when these had worn off, but the rates of responding were still depressed. Chlordiazepoxide potentiated the action of pentobarbital. These results are inte

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Author

M. E. Olds

Publisher

Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 0033-3158)

Published

1972

Language

EN

Field

Neuroscience (Life Sciences)