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Direct and indirect interactions between cannabinoid CB1 receptor and group II metabotropic glutamate receptor signalling in layer V pyramidal neurons from the rat prefrontal cortex by Jean-Gaël Barbara; Nathalie Auclair; Marie-Paule Roisin; Satoru Otani; Emmanuel Valjent; Jocelyne Caboche; Philippe Soubrie; Francis Crepel is a Neuroscience article available to read on EtoBox.
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## Abstract At proximal synapses from layer V pyramidal neurons from the rat prefrontal cortex, activation of group II metabotropic glutamate receptors (group II mGlu) by (2S,2′R,3′R)‐2‐(2′,3′‐dicarboxycyclopropyl) glycine (DCG IV) induced a long‐lasting depression of excitatory postsynaptic currents. Paired‐pulse experiments suggested that the depression was expressed presynaptically. Activation of type 1 cannabinoid receptors (CB1) by WIN 55,212‐2 occluded the DCG IV‐induced depression in a mutually occlusive manner. At the postsynaptic level, WIN 55,212‐2 and DCG IV were also occlusive for the activation of extracellular signal‐regulated kinase. The postsynaptic localization of active extracellular signal‐regulated kinase was confirmed by immunocytochemistry after activation of CB1 receptors. However, phosphorylation of extracellular signal‐regulated kinase in layer V pyramidal neurons was dependent on the activation of __N__‐methyl‐d‐aspartate receptors, consequently to a release of glutamate in the local network. Group II mGlu were also shown to be involved in long‐term changes in synaptic plasticity induced by high frequency stimulations. The group II mGlu antagonist (RS)‐alp
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- Author
- Jean-Gaël Barbara; Nathalie Auclair; Marie-Paule Roisin; Satoru Otani; Emmanuel Valjent; Jocelyne Caboche; Philippe Soubrie; Francis Crepel
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0953-816X)
- Published
- 2003
- Language
- EN
- Field
- Neuroscience (Life Sciences)