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A Novel Treatment Approach to Treatment-Resistant, Recurrent Clostridium difficile by Megha Gangadhar; Anita Kottapalli; Ven Kottapalli is a Medicine article available to read on EtoBox.

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## Abstract A 36-year-old male with a previous medical history of persistent __Clostridium difficile__ presented to clinic for evaluation of diarrheal symptoms intermittently for the last 2 years. He reported recurrent episodes of __C. difficile__ that initially began after prophylactic antibiotic use prior to a tooth extraction. He underwent 12 unsuccessful treatment trials at a nearby clinic with courses of vancomycin, metronidazole, and fidaxomicin. His chronic diarrhea had caused him to endure significant lifestyle alterations over the years. After multiple episodes of incomplete bacterial clearance, he was referred to a university-based tertiary care facility but instead opted for care at a nearby clinic. Upon work-up, his serology was again positive for __C. difficile__, and he was initiated on a 14-day course of fidaxomicin 200 mg p.o. BID, along with yogurt and probiotic supplementation. Despite fidaxomicin treatment, subsequent serological PCR testing for __C. difficile__ remained positive, consistent with CT abdomen and pelvis findings suspicious for enteritis. His recurrent resistance to standard therapy protocols inspired an unconventional treatment approach: another 14

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Author

Megha Gangadhar; Anita Kottapalli; Ven Kottapalli

Publisher

S. Karger AG

Published

2022

Language

EN

Field

Medicine (Health Sciences)