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Molecular dynamics of solid furosemide (4-chloro-2-furfurylamino-5-sulfamoyl-benzoic acid) studied by NMR and DFT methods by J.N. Latosińska; M. Latosińska; W. Medycki; J. Osuchowicz is a Physics and Astronomy article available to read on EtoBox.

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This Letter reports the temperature dependencies of the relaxation time T 1 (in the ranges: 100-440 K at 60 MHz; 20 K-RT at 24.667 MHz) and the second moment of the NMR line for protons (in the range: 100-350 K, 27 MHz) measured for a polycrystalline sample of 4-chloro-2-furfurylamino-5-sulfamoyl-benzoic acid (furosemide), form I. The minima in the temperature dependence of the T 1 time revealed two activation processes related to the proton transfer in the O-HÁ Á ÁO hydrogen bond (the low-temperature minimum) and a jumps of the -NH 2 group (the high-temperature minimum). The reduction in the second moment value M 2 indicated a global motion of the compound molecule, a quasi-isotropic tumbling motion.

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Author

J.N. Latosińska; M. Latosińska; W. Medycki; J. Osuchowicz

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0009-2614)

Published

2006

Language

EN

Field

Physics and Astronomy (Physical Sciences)