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Can I read Treatment with Mesenchymal-Derived Extracellular Vesicles Reduces Injury-Related Pathology in Pyramidal Neurons of Monkey Perilesional Ventral Premotor Cortex on EtoBox?
Treatment with Mesenchymal-Derived Extracellular Vesicles Reduces Injury-Related Pathology in Pyramidal Neurons of Monkey Perilesional Ventral Premotor Cortex by Maria Medalla; Wayne Chang; Samantha M. Calderazzo; Veronica Go; Alexandra Tsolias; Joseph W. Goodliffe; Dhruba Pathak; Diego De Alba; Monica Pessina; Douglas L. Rosene; Benjamin Buller; Tara L. Moore is a Neuroscience article available to read on EtoBox.
What is Treatment with Mesenchymal-Derived Extracellular Vesicles Reduces Injury-Related Pathology in Pyramidal Neurons of Monkey Perilesional Ventral Premotor Cortex about?
Functional recovery after cortical injury, such as stroke, is associated with neural circuit reorganization, but the underlying mechanisms and efficacy of therapeutic interventions promoting neural plasticity in primates are not well understood. Bone marrow mesenchymal stem cell-derived extracellular vesicles (MSC-EVs), which mediate cell-to-cell inflammatory and trophic signaling, are thought be viable therapeutic targets. We recently showed, in aged female rhesus monkeys, that systemic administration of MSC-EVs enhances recovery of function after injury of the primary motor cortex, likely through enhancing plasticity in perilesional motor and premotor cortices. Here, usingin vitrowhole-cell patch-clamp recording and intracellular filling in acute slices of ventral premotor cortex (vPMC) from rhesus monkeys (Macaca mulatta) of either sex, we demonstrate that MSC-EVs reduce injury-related physiological and morphologic changes in perilesional layer 3 pyramidal neurons. At 14-16 weeks after injury, vPMC neurons from both vehicle- and EV-treated lesioned monkeys exhibited significant hyperexcitability and predominance of inhibitory synaptic currents, compared with neurons from nonlesi
Who reads Treatment with Mesenchymal-Derived Extracellular Vesicles Reduces Injury-Related Pathology in Pyramidal Neurons of Monkey Perilesional Ventral Premotor Cortex?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Maria Medalla; Wayne Chang; Samantha M. Calderazzo; Veronica Go; Alexandra Tsolias; Joseph W. Goodliffe; Dhruba Pathak; Diego De Alba; Monica Pessina; Douglas L. Rosene; Benjamin Buller; Tara L. Moore
- Publisher
- Society for Neuroscience (ISSN 0270-6474)
- Published
- 2020
- Language
- EN
- Field
- Neuroscience (Life Sciences)