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Development of highly sensitive, flexible dual L-glutamate and GABA microsensors for in vivo brain sensing by Sung Sik Chu; Hung Anh Nguyen; Derrick Lin; Mehwish Bhatti; Carolyn E. Jones-Tinsley; An Hong Do; Ron D. Frostig; Zoran Nenadic; Xiangmin Xu; Miranda M. Lim; Hung Cao is a Engineering article available to read on EtoBox.

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Real-time tracking of neurotransmitter levels in vivo has been technically challenging due to the low spatiotemporal resolution of current methods. Since the imbalance of cortical excitation/inhibition (E:I) ratios are associated with a variety of neurological disorders, accurate monitoring of excitatory and inhibitory neurotransmitter levels is crucial for investigating the underlying neural mechanisms of these conditions. Specifically, levels of the excitatory neurotransmitter L-glutamate, and the inhibitory neurotransmitter GABA, are assumed to play critical roles in the E:I balance. Therefore, in this work, a flexible electrochemical microsensor is developed for real-time simultaneous detection of L-glutamate and GABA. The flexible polyimide substrate was used for easier handling during implantation and measurement, along with less brain damage. Further, by electrochemically depositing Pt-black nanostructures on the sensor’s surface, the active surface area was enhanced for higher sensitivity. This dual neurotransmitter sensor probe was validated under various settings for its performance, including in vitro, ex vivo tests with glutamatergic neuronal cells and in vivo test with

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Author

Sung Sik Chu; Hung Anh Nguyen; Derrick Lin; Mehwish Bhatti; Carolyn E. Jones-Tinsley; An Hong Do; Ron D. Frostig; Zoran Nenadic; Xiangmin Xu; Miranda M. Lim; Hung Cao

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Engineering (Physical Sciences)