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Alterations of Neutrophil F-actin Kinetics by Tobacco Smoke: Implications for Periodontal Diseases by Mark I. Ryder; Timothy C. Wu; Steven S. Kallaos; William Hyun is a Dentistry article available to read on EtoBox.

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Tobacco smoking is a major risk factor in the incidence and severity of periodontal diseases. Alterations of neutrophil function by short‐term high levels of smoke during the act of smoking (acute smoke exposure) as well as long‐term exposure to lower levels of tobacco substances in the bloodstream (chronic smoke exposure) may play a role in the pathogenesis of periodontal diseases in smokers. The polymerization and depolymerization of f‐actin in response to infectious agents or inflammatory mediators is a critical process in a variety of neutrophil functions. In this study, we examined the effects of __in vitro__ smoke exposure on neutrophils from smokers and non‐smokers (which may be comparable to __in vivo__ acute smoke exposure) and neutrophils from smokers not exposed to further __in vitro__ smoke (which may be comparable to chronic smoke exposure) on f‐actin kinetics. Peripheral neutrophils were isolated from seven healthy smoking subjects and seven healthy age‐matched non‐smoking subjects and exposed to 1–5 min of acute smoke in a smoke box system or not exposed to further smoke (baseline controls). Selected aliquots of neutrophils from control and 5‐min exposures of acute s

Who reads Alterations of Neutrophil F-actin Kinetics by Tobacco Smoke: Implications for Periodontal Diseases?

Author

Mark I. Ryder; Timothy C. Wu; Steven S. Kallaos; William Hyun

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0022-3484)

Published

2002

Language

EN

Field

Dentistry (Health Sciences)