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CD5‐positive chronic B‐cell lymphoproliferative disorders: Diagnosis and prognosis of a heterogeneous disease entity by Roxana S. Dronca; Dragan Jevremovic; Curtis A. Hanson; Kari G. Rabe; Tait D. Shanafelt; William G. Morice; Timothy G. Call; Neil E. Kay; Charles S. Collins; Susan M. Schwager; Susan L. Slager; Clive S. Zent is a Medicine article available to read on EtoBox.
What is CD5‐positive chronic B‐cell lymphoproliferative disorders: Diagnosis and prognosis of a heterogeneous disease entity about?
## Abstract ## Background: The pathology and clinical course of patients with CD5+ chronic B‐cell lymphoproliferative disorders, excluding those that present with typical chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL) or mantle cell lymphoma, (i.e. CD5+B‐CLPD) are poorly defined. ## Methods: We studied patients with CD5+B‐CLPD to (1) more completely define the clinical features and pathology of CD5+B‐CLPD, (2) compare these features to patients presenting with typical CLL, and (3) test the hypothesis that a subset of patients with CD5+B‐CLPD could have a unique B‐cell malignancy. ## Results: We identified 229 patients with CD5+B‐CLPD. A definitive pathological diagnosis was made in all 61 (27%) CD5+B‐CLPD patients with nonbone marrow (BM) biopsy specimens considered adequate for a comprehensive pathological examination. The most common diagnosis among these 61 patients was CLL (44%) followed by the leukemic phase of marginal zone lymphoma (34%), lymphoplasmacytic lymphoma (11%), diffuse large B cell lymphoma (8%), and high‐grade B cell lymphoma not otherwise specified (2%). In contrast, among 168 patients without a non‐BM tissue biopsy specimen, a specific diagnosis
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- Author
- Roxana S. Dronca; Dragan Jevremovic; Curtis A. Hanson; Kari G. Rabe; Tait D. Shanafelt; William G. Morice; Timothy G. Call; Neil E. Kay; Charles S. Collins; Susan M. Schwager; Susan L. Slager; Clive S. Zent
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 1552-4949)
- Published
- 2010
- Language
- EN
- Field
- Medicine (Health Sciences)