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Aminoglycosides are a class of antibiotics that include streptomycin, gentamicin, and tobramycin. They are effective against aerobic gram-negative bacteria and work by binding to the 30S ribosomal subunit and interfering with protein synthesis. Their use requires monitoring due to the risks of ototoxicity and nephrotoxicity, especially in patients with renal impairment. Dosing should be adjusted based on creatinine clearance levels.
- Author
- Shahid Iqbal
- Language
- EN