Can I read Cyclical binding, processing, and functional interactions of neutrophils with leukotriene B~4~ on EtoBox?

Cyclical binding, processing, and functional interactions of neutrophils with leukotriene B~4~ by Joseph T. O'Flaherty; Jimmy F. Redman; David P. Jacobson is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Cyclical binding, processing, and functional interactions of neutrophils with leukotriene B~4~ about?

## Abstract Leukotrene (LT) B~4~ activates human polymorphonuclear neutrophils. (PMN) by binding to plasmalemmal receptors. It stimulates PMN to raise cytosolic calcium and degranulate. Both responses end within 15–30 sec. However, in < 15 sec, LTB~4~‐treated PMN lose the ability to respond further to LTB~4~; decrease the affinity and number of high affinity receptors available for binding LTB~4~ sequester LTB~4~ in plasmalemma‐associated sites that are inaccessible to a releasing buffei regi i men; and begin internalizing LTB~4~. Over the next 90 min, the cells increasingly internalize LTB~4~ and convert it to less potent metabolites; release the metabolites; recover LTB~4~ binding sites; and become fully sensitive to LTB~4~. Contrastingly, during the entire 90 min incubation with LTB~4~. PMN retained the capacity to bind and respond normally to a second stimulus platelet‐activating factor. We therefore suggest the following model. LTB~4~ receptors, when ligand‐bound, initiate function but rapidly lose this capacity as they lower their ligand binding affinity and sequester, internalize, or otherwise uncouple from transducing elements. These LTB~4~ receptor changes contribute to te

Who reads Cyclical binding, processing, and functional interactions of neutrophils with leukotriene B~4~?

Author

Joseph T. O'Flaherty; Jimmy F. Redman; David P. Jacobson

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0021-9541)

Published

1990

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)