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Can I read Topiramate: A novel protective agent against ischemia reperfusion-induced oxidative injury after testicular torsion/detorsion on EtoBox?
Topiramate: A novel protective agent against ischemia reperfusion-induced oxidative injury after testicular torsion/detorsion by Jafari, Abbas; Ghasemnejad-Berenji, Hojat; Nemati, Mohadeseh; Ghasemnejad-Berenji, Morteza is a Medicine article available to read on EtoBox.
What is Topiramate: A novel protective agent against ischemia reperfusion-induced oxidative injury after testicular torsion/detorsion about?
Testicular torsion is a common urologic emergency and one of the causes of genital injury in males. Hence, early diagnosis and treatment are necessary to prevent testicular damage and infertility. It has been proved that topiramate (TPM) a medication used to treat epilepsy and prevent migraines has anti-inflammatory and anti-oxidative effects. Therefore, this study was designed to determine the influence of TPM on ischemia/reperfusion injury following testicular torsion/detorsion (T/D). Thirty-six male Wistar rats were divided into three groups (n = 12 for each group) including sham operated, T/D + vehicle, T/D + TPM(100 mg/kg, 30 min before detorsion). Testicular torsion was induced for 1 h by rotating right testis 720 in the clockwise direction. After 5 h of reperfusion the testis was removed and histological changes and biochemical markers such as superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and levels of malondialdehyde (MDA) and reduced glutathione (GSH) were evaluated. MDA level significantly increased and GSH level significantly decreased after T/D compared to the sham group (p < 0.001). Moreover, after inducing testicular T/D, GPx, CAT and SOD ac
Who reads Topiramate: A novel protective agent against ischemia reperfusion-induced oxidative injury after testicular torsion/detorsion?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Jafari, Abbas; Ghasemnejad-Berenji, Hojat; Nemati, Mohadeseh; Ghasemnejad-Berenji, Morteza
- Publisher
- Elsevier Science; Elsevier ; W. B. Saunders Co., Ltd.; Elsevier BV (ISSN 1532-8171)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)