Can I read Familial pseudohyperkalaemia Chiswick: a novel congenital thermotropic variant of K and Na transport across the human red cell membrane on EtoBox?

Familial pseudohyperkalaemia Chiswick: a novel congenital thermotropic variant of K and Na transport across the human red cell membrane by Philip G. Haines; Charles Crawley; Margaret C. Chetty; Helen Jarvis; Suzanne E. Coles; Julie Fisher; Anna Nicolaou; Gordon W. Stewart is a Medicine article available to read on EtoBox.

What is Familial pseudohyperkalaemia Chiswick: a novel congenital thermotropic variant of K and Na transport across the human red cell membrane about?

Two families with inherited abnormalities in Na and K transport across the red cell membrane are described. Both presented with ‘pseudohyperkalaemia’ as a result of loss of K from the red cells on storage at room temperature. Routine haematology was essentially normal, except for macrocytosis in one family. Studies of the temperature dependence of the passive leak to K showed a novel shoulder pattern with a minimum at 25°C, a maximum at 10°C, followed by a further fall. As in other cases of red cell‐based pseudohyperkalaemia, the abnormal temperature dependence of this ‘leak’ flux could be held to account for the loss of K from the cells at room temperature. These cases represent a novel variant of the temperature dependence of the passive leak of K and Na across the red cell membrane, and can be classified as a mild, non‐haemolytic form of the group known as the hereditary stomatocytosis and allied disorders’.

Who reads Familial pseudohyperkalaemia Chiswick: a novel congenital thermotropic variant of K and Na transport across the human red cell membrane?

Author

Philip G. Haines; Charles Crawley; Margaret C. Chetty; Helen Jarvis; Suzanne E. Coles; Julie Fisher; Anna Nicolaou; Gordon W. Stewart

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0007-1048)

Published

2001

Language

EN

Field

Medicine (Health Sciences)