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Can I read 865 Sugar high: Does the sialic acid profile of cancer-associated fibroblasts induce a more tumour-permissive microenvironment? on EtoBox?
865 Sugar high: Does the sialic acid profile of cancer-associated fibroblasts induce a more tumour-permissive microenvironment? by Egan, Hannah ;Treacy, Oliver ;Lynch, Kevin ;Leonard, Niamh ;Nader, Amir ;Sheehan, Margaret ;Hynes, Sean ;Egan, Laurence ;Ritter, Thomas ;Daly, John ;Hogan, Aisling ;Michael, O ;Ryan, Aideen is a Medicine article available to read on EtoBox.
What is 865 Sugar high: Does the sialic acid profile of cancer-associated fibroblasts induce a more tumour-permissive microenvironment? about?
Background Immunosuppressive tumour microenvironments (TME) inhibit the effectiveness of cancer immunotherapies. Sialic acids, which exist as terminal sugars of glyco-conjugates, are highly expressed on cancer cells and are involved in various pathological processes including increased immune evasion, tumour invasiveness and tumour cell metastasis.1 Siglecs (Sialic acid-binding immunoglobulin-type lectins) are expressed on immune cell surfaces and bind sialic acid. Siglec binding to hypersialylated tumour glycans blocks immune cell activation to promote immunosuppression.1 2Intestinal stromal cells (iSCs), precursors to cancer-associated fibroblasts (CAFs), are a key component of the TME and play a vital role in tumour progression by enhancing a tumour-promoting microenvironment. The aim of this study was therefore to investigate if iSC/CAF sialylation contributes to enhanced immunosuppression in the TME. Methods iSCs were isolated from colorectal cancer patient biopsies and cultured ex vivo. Informed consent was obtained from all patients prior to sampling. Tumour-derived iSCs were termed CAFs while control iSCs, isolated from tumour-adjacent non-cancerous tissue, were termed norm
Who reads 865 Sugar high: Does the sialic acid profile of cancer-associated fibroblasts induce a more tumour-permissive microenvironment??
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- Author
- Egan, Hannah ;Treacy, Oliver ;Lynch, Kevin ;Leonard, Niamh ;Nader, Amir ;Sheehan, Margaret ;Hynes, Sean ;Egan, Laurence ;Ritter, Thomas ;Daly, John ;Hogan, Aisling ;Michael, O ;Ryan, Aideen
- Publisher
- BMJ Publishing Group Ltd
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)