Opening book details…
Can I read Mutational analysis of the class I β-tubulin gene in human breast cancer on EtoBox?
Mutational analysis of the class I β-tubulin gene in human breast cancer by Seiichi Hasegawa; Yasuo Miyoshi; Chiyomi Egawa; Makoto Ishitobi; Yasuhiro Tamaki; Morito Monden; Shinzaburo Noguchi is a Medicine article available to read on EtoBox.
What is Mutational analysis of the class I β-tubulin gene in human breast cancer about?
Non-small cell lung cancers have a high incidence of somatic mutations of the beta-tubulin (class I) gene, suggesting involvement in the acquisition of resistance to taxanes, which exert their effects through binding to beta-tubulin. Since taxanes are often used in the treatment of breast cancer, we carried out a mutational analysis of the class I beta-tubulin (GenBank accession AF070600) gene in breast cancer. We paid special attention to the primer design so as not to amplify the pseudogenes. We identified 1 somatic mutation, codon 306 [Arg (CGC) to Cys (TGC)], and 2 genetic polymorphisms, codon 217 [Leu (CTG) to Leu (CTA)] and (C to T) at 57 bases downstream from exon 4. Our results suggest that acquisition of resistance to taxanes is unlikely to be explained by somatic mutations of the class I beta-tubulin gene in most breast cancers. In addition, the overestimation of the incidence of somatic mutations of the class I beta-tubulin gene due to the pseudogenes is discussed.
Who reads Mutational analysis of the class I β-tubulin gene in human breast cancer?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Seiichi Hasegawa; Yasuo Miyoshi; Chiyomi Egawa; Makoto Ishitobi; Yasuhiro Tamaki; Morito Monden; Shinzaburo Noguchi
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 2002
- Language
- EN
- Field
- Medicine (Health Sciences)