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Expression Profiles of Angiogenic Growth Factors in Squamous Cell Carcinomas of the Head and Neck by Simon Ninck; Christoph Reisser; Gerhard Dyckhoff; Burkhard Helmke; Harald Bauer; Christel Herold-Mende is a Medicine article available to read on EtoBox.

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## Abstract Inhibition of angiogenesis by blocking angiogenic cytokines or their pathways has become a major target in experimental cancer therapies. This therapeutical approach requires a profound knowledge of growth factor profiles that contribute to tumor growth and progression. The respective knowledge is presently rather incomplete for head and neck squamous cell carcinomas (HNSCC). Therefore we studied expression of several angiogenic cytokines including VEGF, bFGF, PDGF‐AB, PDGF‐BB, G‐CSF and GM‐CSF in HNSCC __in vivo__ and __in vitro__. In tumor tissues expression of all cytokines was observed albeit with marked differences concerning intensity and distribution pattern. Quantification of the cytokines in the supernatant of 15 tissue‐corresponding HNSCC cultures revealed that VEGF, PDGF‐AB and less frequently GM‐CSF were secreted in high amounts of up to 13 ng/ml/10^6^ cells. Twenty percent of the HNSCC cultures expressed only 1 cytokine in biologically active amounts, 60% 2 or 3 and 20% expressed the maximum of 4 cytokines simultaneously. Interestingly, we observed a distinct cytokine pattern: HNSCC cells secreting only 1 or 2 cytokines presented always with either VEGF and

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Author

Simon Ninck; Christoph Reisser; Gerhard Dyckhoff; Burkhard Helmke; Harald Bauer; Christel Herold-Mende

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

2003

Language

EN

Field

Medicine (Health Sciences)