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Can I read SAT-125 A Tough NUT (Midline Carcinoma) to Crack on EtoBox?
SAT-125 A Tough NUT (Midline Carcinoma) to Crack by Kristen Lavelle; Kjersti Kirkeby is a Medicine article available to read on EtoBox.
What is SAT-125 A Tough NUT (Midline Carcinoma) to Crack about?
## Abstract Introduction NUT midline carcinoma (NMC) is a rare, highly aggressive cancer with poor prognosis. To date, there is no established therapeutic strategy; further studies are necessary to compare treatment modalities as well as investigate novel immunotherapeutic agents. Case presentation A 39-year-old female presented with a rapidly enlarging right neck mass and a recent 40-lb weight loss and was found to have a 5 cm poorly defined infiltrative hypoattenuating mass on CT scan concerning initially for anaplastic thyroid malignancy. Endocrinology and ENT were consulted and the patient underwent thyroid biopsy, which was positive for NMC. PET scan demonstrated hypermetabolic lymphadenopathy in the bilateral neck and mediastinum, but no distant metastases were identified. She then underwent total thyroidectomy with extensive dissection of the bilateral neck; pathology revealed one positive lymph node. On endobronchial biopsy, the mediastinal lymph nodes were benign. Immunohistochemistry revealed PD-L1 expression and gene assay showed an NSD3-NUTM1 fusion of the NUT gene. Oncology advised systemic treatment with carboplatin/taxol and considered Pembrolizimab, an anti-PD-L1 im
Who reads SAT-125 A Tough NUT (Midline Carcinoma) to Crack?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Kristen Lavelle; Kjersti Kirkeby
- Publisher
- The Endocrine Society
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)