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Can I read Engineering Nonphotosynthetic Carbon Fixation for Production of Bioplastics by Methanogenic Archaea on EtoBox?
Engineering Nonphotosynthetic Carbon Fixation for Production of Bioplastics by Methanogenic Archaea by Kershanthen Thevasundaram; Joseph J. Gallagher; Freeman Cherng; Michelle C. Y. Chang is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Engineering Nonphotosynthetic Carbon Fixation for Production of Bioplastics by Methanogenic Archaea about?
## Significance Biological carbon fixation provides opportunities to directly utilize CO~2~ to synthesize a broad range of value-added compounds, potentially displacing petroleum feedstock use in industry. Chemoautotrophs are particularly interesting as their carbon fixation can be driven chemically by renewable H~2~ in place of light, which can limit industrial fermentation of photosynthetic organisms. We describe the development of a methanogenic host, __Methanococcus maripaludis__, for metabolic engineering. Since redox cofactors used in upstream archaeal carbon fixation pathways are orthogonal to typical downstream biosynthetic pathways, it was necessary to engineer both NADH biosynthesis and turnover. In doing so, we are able to show that methanogenic archaea can, indeed, serve as a platform for the high-yield production of bioplastics and monomers from CO~2~ and H~2~.
Who reads Engineering Nonphotosynthetic Carbon Fixation for Production of Bioplastics by Methanogenic Archaea?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Kershanthen Thevasundaram; Joseph J. Gallagher; Freeman Cherng; Michelle C. Y. Chang
- Publisher
- Proceedings of the National Academy of Sciences
- Published
- 2022
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)