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Metronidazole Susceptibility Testing of Anaerobic Bacteria Associated with Periodontal Disease by P. P. Poulet; D. Duffaut; J. Ph. Lodter is a Dentistry article available to read on EtoBox.

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__Abstract__. The aim of the present investigation was to determine the susceptibility of __Prevotella intermedia__, __Porphyromonas gingivalis__, Fusobacterium and __Peptostreptococcus micros__ to metronidazole in vitro. Two methods were applied on each isolated strain: agar dilution and epsilometer Etest®. A total of fifty three wild test strains (13 __P.intermedia__, 14 __P.gingivalis__, 14 __F.spp__ and __12 P.micros__) were isolated from patients with periodontitis. The Etest® appears to be a simple, rapid and reliable method for the metronidazole susceptibility testing. The results show that all __P.intermedia__, __P.gingivalis__ and __F.spp__ strains were susceptible to metronidazole. The mean values of minimal inhibitory concentration obtained with the agar dilution method were, respectively, 0.98 μg/ml, 0.122 μg/ml and 0.242 μg/ml. For __P. micros__, the minimal inhibitory concentration was of 12.14 μg/ml. Comparatively to break points, only 60% of __P.micros__ strains seem to be susceptible, in vitro, to metronidazole. This study demonstrated the excellent activity of metronidazole against __P.intermedia__, __P.gingivalis__, __F.spp__ except perhaps for __P.micros__.

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Author

P. P. Poulet; D. Duffaut; J. Ph. Lodter

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0303-6979)

Published

1999

Language

EN

Field

Dentistry (Health Sciences)