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Development and regional expression of chicken neuroleukin (glucose-6-phosphate isomerase) messenger RNA: Neuroleukin mRNA During Development by F. Hallböök; H. Persson; G. Barbany; T. Ebendal is a Neuroscience article available to read on EtoBox.

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T.E.), Sweden Neuroleukin (NLK) is a protein identical with the glycolytic enzyme glucose-Qphosphate isomerase (GPI) that has been reported to support the survival of a subpopulation of neurons in embryonic dorsal root ganglia and spinal cord neurons in culture. In this report we have studied the developmental expression of NLK mRNA in the chick embryo in order to evaluate its possible role as a neurotrophic factor. The chicken gene encoding NLK was isolated by cross-hybridization to a mouse NLK cDNA clone. A DNA fragment from the chicken NLK gene with a 90% nucleotide sequence homology to mouse NLK cDNk encoding amino acids 310-355 was then used as a hybridization probe in a series of RNA-blots. In the entire embryo NLK mRNA was found already at embryonic day 3.5 (E3.5) and the level of expression was significantly decreased between E3.5 and hatching. Roughly similar levels of NLK mRNA were found in all tissues of the ES embryo analyzed, with the exception of the brain, which contained only low levels. When the developmental expression was analyzed in different tissues separately, NLK mRNA expression was found to decrease during development in the heart and bursa of Fabricius, whe

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Author

F. Hallböök; H. Persson; G. Barbany; T. Ebendal

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0360-4012)

Published

1989

Language

EN

Field

Neuroscience (Life Sciences)