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Retinal Vascular and Anatomical Features in the Spontaneously Hypertensive Rat by Li, Yunxia; Wang, Qian; Muir, Eric R.; Kiel, Jeffrey W.; Duong, Timothy Q. is a Medicine article available to read on EtoBox.

What is Retinal Vascular and Anatomical Features in the Spontaneously Hypertensive Rat about?

: To evaluate whether optical imaging methods and histology can detect comparable vascular and neuronal damage in the retina due to the effects of progressive chronic hypertension on the retinal vasculature and neurons using the spontaneously hypertensive rat (SHR) model at young and old ages. : Male SHR and normotensive Wistar Kyoto (WKY) rats were studied at 10 and 40 weeks of age (n = 6 each group). Arterial blood pressure was measured with a tail-cuff. Under anesthesia, fundus photography was used to measure retinal arterial diameters and optical coherence tomography was used to measure retinal layer thicknesses. Histology was then used to measure microvascular and cell density in different retinal layers. : Blood pressure was significantly higher in SHR than WKY in both age groups ( < .05). Fundus images showed no gross abnormalities, hemorrhage, or stenosis in all groups. Retinal vessels, however, appeared more tortuous in SHR compared to WKY at both ages. Retinal vessel diameters in SHR were significantly narrower than in WKY at both age groups ( .05) but were markedly reduced in SHR at 40 weeks compared to WKY ( < .05). The outer nuclear layer thickness of SHR was signifi

Who reads Retinal Vascular and Anatomical Features in the Spontaneously Hypertensive Rat?

Author

Li, Yunxia; Wang, Qian; Muir, Eric R.; Kiel, Jeffrey W.; Duong, Timothy Q.

Publisher

Informa plc; Informa UK (Informa Healthcare); Taylor & Francis; Swets & Zeitlinger Publishers; Informa UK Limited (ISSN 6854-1423)

Published

2020

Language

EN

Field

Medicine (Health Sciences)