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In-hospital Antibiotic Use for Severe Chronic Obstructive Pulmonary Disease Exacerbations: a Retrospective Observational Study by Anna Vanoverschelde; Chloë Van Hoey; Franky Buyle; Nadia Den Blauwen; Pieter Depuydt; Eva Van Braeckel; Lies Lahousse is a Medicine article available to read on EtoBox.
What is In-hospital Antibiotic Use for Severe Chronic Obstructive Pulmonary Disease Exacerbations: a Retrospective Observational Study about?
## Background The use of antibiotics in mild to severe acute exacerbations of chronic obstructive pulmonary disease (COPD) remains controversial. ## Aim To explore in-hospital antibiotic use in severe acute exacerbations of COPD (AECOPD), to analyze determinants of in-hospital antibiotic use, and to investigate its association with hospital length of stay (LOS) and in-hospital mortality. ## Methods A retrospective, observational study was conducted in Ghent University Hospital. Severe AECOPD were defined as hospitalizations for AECOPD (ICD-10 J44.0 and J44.1) discharged between 2016 and 2021. Patients with a concomitant diagnosis of pneumonia or ‘pure’ asthma were excluded. An alluvial plot was used to describe antibiotic treatment patterns. Logistic regression analyses identified determinants of in-hospital antibiotic use. Cox proportional hazards regression analyses were used to compare time to discharge alive and time to in-hospital death between antibiotic-treated and non-antibiotic-treated AECOPD patients. ## Results In total, 431 AECOPD patients (mean age 70 years, 63% males) were included. More than two-thirds (68%) of patients were treated with antibiotics, mainly amoxicill
Who reads In-hospital Antibiotic Use for Severe Chronic Obstructive Pulmonary Disease Exacerbations: a Retrospective Observational Study?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Anna Vanoverschelde; Chloë Van Hoey; Franky Buyle; Nadia Den Blauwen; Pieter Depuydt; Eva Van Braeckel; Lies Lahousse
- Publisher
- Springer Science and Business Media LLC
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)