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High-dose intravenous melphalan with autologous stem cell transplantation in AL amyloidosis-associated end-stage renal disease by Liam F. Casserly; Amit Fadia; Vaishali Sanchorawala; David C. Seldin; Daniel G. Wright; Martha Skinner; Laura M. Dember is a Medicine article available to read on EtoBox.

What is High-dose intravenous melphalan with autologous stem cell transplantation in AL amyloidosis-associated end-stage renal disease about?

## Background: The development of end-stage renal disease (esrd) is common among patients with amyloid light-chain al amyloidosis-associated renal disease and survival of these patients is poor. high-dose intravenous melphalan and autologous stem cell transplantation induce remission of the plasma cell dyscrasia in a significant proportion of patients with al amyloidosis. the efficacy and tolerability of such treatment for patients with al amyloidosis-associated esrd are unknown. ## Methods: Between june 1994 and june 2000, 15 patients with al amyloidosis-associated esrd were treated with intravenous melphalan (70 to 200 mg/m2) and autologous peripheral blood stem cell transplantation. clinical and laboratory data were prospectively collected prior to treatment, during the peritransplant period, and at 3 months, 12 months, and annually thereafter. treatment outcomes and toxicities were compared with 180 non-esrd patients treated during the study period. ## Results: Eight of 15 patients (53%) had a hematologic complete response following treatment. two patients (13%) died during the peritransplant period. transfusion requirements were greater and there was a trend toward increased s

Who reads High-dose intravenous melphalan with autologous stem cell transplantation in AL amyloidosis-associated end-stage renal disease?

Author

Liam F. Casserly; Amit Fadia; Vaishali Sanchorawala; David C. Seldin; Daniel G. Wright; Martha Skinner; Laura M. Dember

Publisher

Nature Publishing Group; Elsevier ; Elsevier Inc.; Elsevier BV; ScienceOpen (ISSN 0085-2538)

Published

2003

Language

EN

Field

Medicine (Health Sciences)