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Can I read Intramuscular Aminotetrazole Cobinamide as a Treatment for Inhaled Hydrogen Sulfide Poisoning in a Large Swine Model on EtoBox?
Intramuscular Aminotetrazole Cobinamide as a Treatment for Inhaled Hydrogen Sulfide Poisoning in a Large Swine Model by Hendry-Hofer, Tara B.; Ng, Patrick C.; McGrath, Alison M.; Mukai, David; Brenner, Matthew; Mahon, Sari; Maddry, Joseph K.; Boss, Gerry R.; Bebarta, Vikhyat S. is a Agricultural and Biological Sciences article available to read on EtoBox.
What is Intramuscular Aminotetrazole Cobinamide as a Treatment for Inhaled Hydrogen Sulfide Poisoning in a Large Swine Model about?
Hydrogen sulfide (H S), a high-threat chemical agent, occurs naturally in a variety of settings. Despite multiple incidents of exposures and deaths, no FDA-approved antidote exists. A rapid-acting, easy to administer antidote is needed. We conducted a randomized control trial in swine comparing intramuscular administration of aminotetrazole cobinamide (2.9 mL, 18 mg/kg) to no treatment following inhalation of H S gas. We found that aminotetrazole cobinamide administered 2 min after the onset of respiratory depression-defined as a tidal volume of less than 3 mL/kg for 2 consecutive minutes-yielded 100% survival, while all control animals died. Respiratory depression resolved in the treatment group within 3.6 ± 1.5 min (mean ± SD) of cobinamide administration, whereas control animals had intermittent gasping until death. Blood pressure and arterial oxygen saturation (SO ) returned to baseline values within 5 and 10 min, respectively, of cobinamide treatment, and plasma lactate concentration decreased to less than 50% of the highest value by the end of the experiment. In control animals, plasma lactate rose continuously until death. We conclude that intramuscular aminotetrazole cobina
Who reads Intramuscular Aminotetrazole Cobinamide as a Treatment for Inhaled Hydrogen Sulfide Poisoning in a Large Swine Model?
It is typically read by researchers, students, and practitioners in Agricultural and Biological Sciences.
- Author
- Hendry-Hofer, Tara B.; Ng, Patrick C.; McGrath, Alison M.; Mukai, David; Brenner, Matthew; Mahon, Sari; Maddry, Joseph K.; Boss, Gerry R.; Bebarta, Vikhyat S.
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); New York Academy of Sciences; Wiley-Blackwell; Wiley; Research Square (ISSN 0890-6564)
- Published
- 2020
- Language
- EN
- Field
- Agricultural and Biological Sciences (Life Sciences)