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Hyaluronan magnetic nanoparticle for mitoxantrone delivery toward CD44-positive cancer cells by Sargazi, Azam; Shiri, Fereshteh; Keikha, Sheida; Majd, Mostafa Heidari is a Materials Science article available to read on EtoBox.

What is Hyaluronan magnetic nanoparticle for mitoxantrone delivery toward CD44-positive cancer cells about?

Hyaluronic acid (HA) is increasingly investigated for biomedical applications such as regenerative medicine, aesthetic medicine, and drug delivery. Accordingly, conjugation of HA to PEGylated MNPs could increase the active targeting ability of nano-drug carriers toward CD44 receptors and be useful in a clinical setting such as drug delivery. So, we chemically conjugated mitoxantrone (MTX) to HA-PEGylated MNPs to use concurrent advantages such as prolong the circulation time, decrease the side effects and delivery toward special tumor cells. Size of the FeO-DPA-PEG-HA-MTX NPs was determined ∼200 nm utilizing FESEM and DLS. Stability analysis confirmed that prepared MNPs were stable in physiological conditions even after 8 days and only 47.3% of MTX was liberated from nanocarriers, in the event that, acidic condition and also presence of protease enzyme accelerated the amount of MTX release to 100% after 8 days of incubation. The in vitro cytotoxicity analysis by MTT assay revealed that viable cell numbers were reduced by 32% when MTX-HA-MNPs were applied against MDA-MB-231 cell lines, while they showed significant decreased cellular cytotoxic effects on cell viability in the MCF-7 c

Who reads Hyaluronan magnetic nanoparticle for mitoxantrone delivery toward CD44-positive cancer cells?

Author

Sargazi, Azam; Shiri, Fereshteh; Keikha, Sheida; Majd, Mostafa Heidari

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0927-7765)

Published

2018

Language

EN

Field

Materials Science (Physical Sciences)