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Crystallographic Studies of Chemically Modified Nucleic Acids: A Backward Glance by Martin Egli; Pradeep S. Pallan is a Agricultural and Biological Sciences article available to read on EtoBox.

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## Abstract Chemically modified nucleic acids (CNAs) are widely explored as antisense oligonucleotide or small interfering RNA (siRNA) candidates for therapeutic applications. CNAs are also of interest in diagnostics, high‐throughput genomics and target validation, nanotechnology and as model systems in investigations directed at a better understanding of the etiology of nucleic acid structure, as well as the physicochemical and pairing properties of DNA and RNA, and for probing protein–nucleic acid interactions. In this article, we review research conducted in our laboratory over the past two decades with a focus on crystal‐structure analyses of CNAs and artificial pairing systems. We highlight key insights into issues ranging from conformational distortions as a consequence of modification to the modulation of pairing strength, and RNA affinity by stereoelectronic effects and hydration. Although crystal structures have only been determined for a subset of the large number of modifications that were synthesized and analyzed in the oligonucleotide context to date, they have yielded guiding principles for the design of new analogs with tailor‐made properties, including pairing speci

Who reads Crystallographic Studies of Chemically Modified Nucleic Acids: A Backward Glance?

Author

Martin Egli; Pradeep S. Pallan

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley (ISSN 1612-1872)

Published

2010

Language

EN

Field

Agricultural and Biological Sciences (Life Sciences)