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Pathway Analysis of Dilated Cardiomyopathy Using Global Proteomic Profiling and Enrichment Maps by Ruth Isserlin; Daniele Merico; Rasoul Alikhani-Koupaei; Anthony Gramolini; Gary D. Bader; Andrew Emili is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Pathway Analysis of Dilated Cardiomyopathy Using Global Proteomic Profiling and Enrichment Maps about?
## Abstract Global protein expression profiling can potentially uncover perturbations associated with common forms of heart disease. We have used shotgun MS/MS to monitor the state of biological systems in cardiac tissue correlating with disease onset, cardiac insufficiency and progression to heart failure in a time‐course mouse model of dilated cardiomyopathy. However, interpreting the functional significance of the hundreds of differentially expressed proteins has been challenging. Here, we utilize improved enrichment statistical methods and an extensive collection of functionally related gene sets, gaining a more comprehensive understanding of the progressive alterations associated with functional decline in dilated cardiomyopathy. We visualize the enrichment results as an Enrichment Map, where significant gene sets are grouped based on annotation similarity. This approach vastly simplifies the interpretation of the large number of enriched gene sets found. For pathways of specific interest, such as Apoptosis and the MAPK (mitogen‐activated protein kinase) cascade, we performed a more detailed analysis of the underlying signaling network, including experimental validation of exp
Who reads Pathway Analysis of Dilated Cardiomyopathy Using Global Proteomic Profiling and Enrichment Maps?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Ruth Isserlin; Daniele Merico; Rasoul Alikhani-Koupaei; Anthony Gramolini; Gary D. Bader; Andrew Emili
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley; Research Square (ISSN 1615-9853)
- Published
- 2010
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)