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YKP1447: Novel Atypical Antipsychotic Agent by Dann Arriaga is a document available to read on EtoBox.
What is YKP1447: Novel Atypical Antipsychotic Agent about?
- YKP1447 is a novel potential atypical antipsychotic agent that selectively binds to serotonin (5-HT2A and 5-HT2C) and dopamine (D2 and D3) receptors. - In behavioral studies using mice and rats, YKP1447 antagonized behaviors induced by apomorphine and DOI, and inhibited behaviors induced by dextroamphetamine, with higher efficacy than other antipsychotics. - YKP1447 showed a higher therapeutic index than other antipsychotics as it produced catalepsy in mice only at much higher doses than those needed to
- Author
- Dann Arriaga
- Language
- EN