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Can I read Genetic Influences of the Microbiota on the Life Span of Drosophila melanogaster on EtoBox?
Genetic Influences of the Microbiota on the Life Span of Drosophila melanogaster by Melinda K. Matthews; Hailey Wilcox; Rachel Hughes; Madeline Veloz; Austin Hammer; Bethany Banks; Amber Walters; Kyle J. Schneider; Corinne E. Sexton; John M. Chaston is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Genetic Influences of the Microbiota on the Life Span of Drosophila melanogaster about?
To better understand how associated microorganisms ("microbiota") influence organismal aging, we focused on the model organism We conducted a metagenome-wide association (MGWA) as a screen to identify bacterial genes associated with variation in the life span. The results of the MGWA predicted that bacterial cysteine and methionine metabolism genes influence fruit fly longevity. A mutant analysis, in which flies were inoculated with strains bearing mutations in various methionine cycle genes, confirmed a role for some methionine cycle genes in extending or shortening fruit fly life span. Initially, we predicted these genes might influence longevity by mimicking or opposing methionine restriction, an established mechanism for life span extension in fruit flies. However, follow-up transcriptome sequencing (RNA-seq) and metabolomic experiments were generally inconsistent with this conclusion and instead implicated glucose and vitamin B metabolism in these influences. We then tested if bacteria could influence life span through methionine restriction using a different set of bacterial strains. Flies reared with a bacterial strain that ectopically expressed bacterial transsulfuration ge
Who reads Genetic Influences of the Microbiota on the Life Span of Drosophila melanogaster?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Melinda K. Matthews; Hailey Wilcox; Rachel Hughes; Madeline Veloz; Austin Hammer; Bethany Banks; Amber Walters; Kyle J. Schneider; Corinne E. Sexton; John M. Chaston
- Publisher
- American Society for Microbiology
- Published
- 2020
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)