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Can I read No association between the WNT2 gene and autistic disorder on EtoBox?
No association between the WNT2 gene and autistic disorder by Pinky A. McCoy; Yujun Shao; Chantelle M. Wolpert; Shannon L. Donnelly; Allison Ashley‐Koch; Heidi L. Abel; Sarah A. Ravan; Ruth K. Abramson; Harry H. Wright; G. Robert DeLong; Michael L. Cuccaro; John R. Gilbert; Margaret A. Pericak‐Vance is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is No association between the WNT2 gene and autistic disorder about?
## Abstract Autistic disorder is a pervasive neurodevelopmental disorder characterized by deficits in language and social communication, as well as stereotyped patterns of behavior. Peak LOD scores from several genomic screening efforts indicate the presence of an autistic disorder susceptibility locus within the distal long arm of human chromosome 7 (7q31‐q35). Wassink et al. [2001: Am J Med Genet 105:406–413] reported that __WNT2__, located at 7q31, influences genetic risk in autistic disorder. These findings were enhanced when examined in a subset of families with severe language impairment. WNT genes encode secreted growth factor–like proteins that participate in growth regulation, differentiation, and tumorigenesis. We tested for genetic association of two __WNT2__ variants in an independent data set of 135 singleton and 82 multiplex families. No significant association was found between autistic disorder and the __WNT2__ genotypes in either the overall data set or in the language‐impaired subset of families. However, differences in allele frequencies of the 3′ UTR single nucleotide polymorphism between the present population and that of Wassink et al. may account for the inab
Who reads No association between the WNT2 gene and autistic disorder?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Pinky A. McCoy; Yujun Shao; Chantelle M. Wolpert; Shannon L. Donnelly; Allison Ashley‐Koch; Heidi L. Abel; Sarah A. Ravan; Ruth K. Abramson; Harry H. Wright; G. Robert DeLong; Michael L. Cuccaro; John R. Gilbert; Margaret A. Pericak‐Vance
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Liss Inc; Wiley (ISSN 0148-7299)
- Published
- 2001
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)