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Effect of Etelcalcetide vs Cinacalcet on Serum Parathyroid Hormone in Patients Receiving Hemodialysis With Secondary Hyperparathyroidism: A Randomized Clinical Trial by Geoffrey A. Block; David A. Bushinsky; Sunfa Cheng; John Cunningham; Bastian Dehmel; Tilman B. Drueke; Markus Ketteler; Reshma Kewalramani; Kevin J. Martin; Sharon M. Moe; Uptal D. Patel; Justin Silver; Yan Sun; Hao Wang; Glenn M. Chertow is a Medicine article available to read on EtoBox.

What is Effect of Etelcalcetide vs Cinacalcet on Serum Parathyroid Hormone in Patients Receiving Hemodialysis With Secondary Hyperparathyroidism: A Randomized Clinical Trial about?

## Importance: Secondary hyperparathyroidism contributes to extraskeletal calcification and is associated with all-cause and cardiovascular mortality. control is suboptimal in the majority of patients receiving hemodialysis. an intravenously (iv) administered calcimimetic could improve adherence and reduce adverse gastrointestinal effects. ## Objective: To evaluate the relative efficacy and safety of the iv calcimimetic etelcalcetide and the oral calcimimetic cinacalcet. ## Design, setting, and participants: A randomized, double-blind, double-dummy active clinical trial was conducted comparing iv etelcalcetide vs oral placebo and oral cinacalcet vs iv placebo in 683 patients receiving hemodialysis with serum parathyroid hormone (pth) concentrations higher than 500 pg/ml on active therapy at 164 sites in the united states, canada, europe, russia, and new zealand. patients were enrolled from august 2013 to may 2014, with end of follow-up in january 2015. ## Interventions: Etelcalcetide intravenously and oral placebo (n = 340) or oral cinacalcet and iv placebo (n = 343) for 26 weeks. the iv study drug was administered 3 times weekly with hemodialysis; the oral study drug was administe

Who reads Effect of Etelcalcetide vs Cinacalcet on Serum Parathyroid Hormone in Patients Receiving Hemodialysis With Secondary Hyperparathyroidism: A Randomized Clinical Trial?

Author

Geoffrey A. Block; David A. Bushinsky; Sunfa Cheng; John Cunningham; Bastian Dehmel; Tilman B. Drueke; Markus Ketteler; Reshma Kewalramani; Kevin J. Martin; Sharon M. Moe; Uptal D. Patel; Justin Silver; Yan Sun; Hao Wang; Glenn M. Chertow

Publisher

American Medical Association (AMA)

Published

2017

Language

EN

Field

Medicine (Health Sciences)