Can I read Formation of VEGF isoform-specific spatial distributions governing angiogenesis: computational analysis on EtoBox?

Formation of VEGF isoform-specific spatial distributions governing angiogenesis: computational analysis by Prakash Vempati; Aleksander S Popel; Feilim Mac Gabhann is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Formation of VEGF isoform-specific spatial distributions governing angiogenesis: computational analysis about?

## Background The spatial distribution of vascular endothelial growth factor A (VEGF) is an important mediator of vascular patterning. Previous experimental studies in the mouse hindbrain and retina have suggested that VEGF alternative splicing, which controls the ability of VEGF to bind to heparan sulfate proteoglycans (HSPGs) in the extracellular matrix (ECM), plays a key role in controlling VEGF diffusion and gradients in tissues. Conversely, proteolysis notably by matrix metalloproteinases (MMPs), plays a critical role in pathological situations by releasing matrix-sequestered VEGF and modulating angiogenesis. However, computational models have predicted that HSPG binding alone does not affect VEGF localization or gradients at steady state. ## Results Using a 3D molecular-detailed reaction-diffusion model of VEGF ligand-receptor kinetics and transport, we test alternate models of VEGF transport in the extracellular environment surrounding an endothelial sprout. We show that differences in localization between VEGF isoforms, as observed experimentally in the mouse hindbrain, as well as the ability of proteases to redistribute VEGF in pathological situations, are consistent with

Who reads Formation of VEGF isoform-specific spatial distributions governing angiogenesis: computational analysis?

Author

Prakash Vempati; Aleksander S Popel; Feilim Mac Gabhann

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, [2006]-; Springer Science and Business Media LLC (ISSN 1752-0509)

Published

2011

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)