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Regulation of the Wilms' tumor gene during spermatogenesis by Katia del Rio-Tsonis; Luis Covarrubias; Jill Kent; Nicholas D. Hastie; Panagiotis A. Tsonis is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Regulation of the Wilms' tumor gene during spermatogenesis about?

Spermatogenesis is the process by which male germ cells develop and mature, a pathway that includes a transition from a mitotic to a meiotic cell cycle. Throughout this pathway, the germ cells are in close contact with their nurturing cells, the Sertoli cells. Sertoli-germ cell interactions are difficult to study in mammals due to the complex cellular organization of their seminiferous tubules. The urodele amphibian testis, however, provides a unique system to study the process of germ cell maturation; it is organized in a gradient-like cystic structure, in which synchronized germ cells can be found within the same cyst. The Wilms' tumor gene (WT1) has been shown to be an essential gene for the formation of the gonads in mice, and it has been implicated in a variety of differentiation processes. The WT1 gene is thus a good candidate for the study of the differentiation processes involved in the maturation of the male germ cells. By using a probe for the urodele WT1 homologue in in situ hybridization studies, as well as an antibody against the WT1 protein in immunohistochemistry studies, we determined that WTl gene expression in Sertoli cells depends on the stage of maturation of th

Who reads Regulation of the Wilms' tumor gene during spermatogenesis?

Author

Katia del Rio-Tsonis; Luis Covarrubias; Jill Kent; Nicholas D. Hastie; Panagiotis A. Tsonis

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1058-8388)

Published

1996

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)