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Can I read Phase IV study of retention on fingolimod versus injectable multiple sclerosis therapies: a randomized clinical trial on EtoBox?
Phase IV study of retention on fingolimod versus injectable multiple sclerosis therapies: a randomized clinical trial by Bruce A.C. Cree; Douglas L. Arnold; Mark Cascione; Edward J. Fox; Ian M. Williams; Xiangyi Meng; Lesley Schofield; Nadia Tenenbaum is a Medicine article available to read on EtoBox.
What is Phase IV study of retention on fingolimod versus injectable multiple sclerosis therapies: a randomized clinical trial about?
Objective: In relapsing-remitting multiple sclerosis (RRMS), suboptimal adherence to injectable disease-modifying therapies (iDMTs; interferon β-1a/b, glatiramer acetate) is common, reducing their effectiveness. Patient retention on oral fingolimod and iDMTs was evaluated in PREFERMS, a randomized, parallel-group, active-controlled, open-label, 48-week study. Methods: Patients were included if they had RRMS, were aged 18-65 years and had Expanded Disability Status Scale score up to 6, enrolled at 117 US study sites, were treatment naïve or had received only one iDMT class. Patients were randomized 1:1 (fingolimod 0.5 mg/day; preselected iDMT) by interactive voice-and-web-response system without blinding, followed up quarterly, and allowed one study-approved treatment switch after 12 weeks, or earlier for efficacy or safety reasons. The primary outcome was patient retention on randomized treatment over 48 weeks. Secondary endpoints included patient-reported outcomes, brain volume loss (BVL), and cognitive function. Results: Analysis of 433/436 patients receiving fingolimod and 428/439 receiving iDMTs showed that patient retention rate was significantly higher with fingolimod than wi
Who reads Phase IV study of retention on fingolimod versus injectable multiple sclerosis therapies: a randomized clinical trial?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Bruce A.C. Cree; Douglas L. Arnold; Mark Cascione; Edward J. Fox; Ian M. Williams; Xiangyi Meng; Lesley Schofield; Nadia Tenenbaum
- Publisher
- SAGE Publications
- Published
- 2018
- Language
- EN
- Field
- Medicine (Health Sciences)