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Can I read Ocular Side Effects of EGFR-Inhibitor ABT-414 in Recurrent Glioblastoma: A Long-Term Safety Study on EtoBox?
Ocular Side Effects of EGFR-Inhibitor ABT-414 in Recurrent Glioblastoma: A Long-Term Safety Study by Raffaele Parrozzani; Giuseppe Lombardi; Edoardo Midena; Davide Londei; Marta Padovan; Giulia Marchione; Mario Caccese; Giulia Midena; Vittorina Zagonel; Luisa Frizziero is a Medicine article available to read on EtoBox.
What is Ocular Side Effects of EGFR-Inhibitor ABT-414 in Recurrent Glioblastoma: A Long-Term Safety Study about?
This study aimed to prospectively evaluate, on a long-term basis, corneal side effects secondary to compassionate administration of epidermal growth factor receptor (EGFR) inhibitor depatuxizumab mafodotin (ABT-414) in patients affected by EGFR-amplified recurrent glioblastoma. Fifteen patients with a median follow-up of 4.3 months after treatment discontinuation were enrolled. Each patient underwent full ophthalmologic examination including corneal confocal microscopy (CCM). No CTCAE grade 4 toxicity and four (27%) grade 3 toxicities were documented during treatment. Ocular symptoms (blurred vision, eye pain, photophobia) were experienced by all patients, reaching maximal severity after the second ABT-414 infusion, with persistence until treatment discontinuation. During treatment, CCM documented specific changes in the corneal epithelium and in the sub-basal nerve plexus layer fibers of all eyes. The median time of symptoms resolution after treatment discontinuation ranged from 38 days (eye pain) to 53 days (photophobia). The median time of signs resolution ranges from 14 days (corneal ulcer) to 38 days (superficial punctate epitheliopathy, corneal stroma edema and intraepithelia
Who reads Ocular Side Effects of EGFR-Inhibitor ABT-414 in Recurrent Glioblastoma: A Long-Term Safety Study?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Raffaele Parrozzani; Giuseppe Lombardi; Edoardo Midena; Davide Londei; Marta Padovan; Giulia Marchione; Mario Caccese; Giulia Midena; Vittorina Zagonel; Luisa Frizziero
- Publisher
- Frontiers Media SA
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)