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Proteinase Bone Morphogenetic Protein 1, but Not Tolloid‐like 1, Plays a Dominant Role in Maintaining Periodontal Homeostasis by Jun Wang; Xudong Xie; Nicole A. Muench; Dawiyat Massoudi; Chunmei Xu; Daniel S. Greenspan; Jian Q. Feng is a Dentistry article available to read on EtoBox.

What is Proteinase Bone Morphogenetic Protein 1, but Not Tolloid‐like 1, Plays a Dominant Role in Maintaining Periodontal Homeostasis about?

## Background: Periodontitis is caused by multiple factors involving a bacterial challenge and a susceptible host, although there is no report on gene mutation directly linked to this common disease. mutations in the proteinase bone morphogenetic protein 1 (bmp1) were identified in patients with osteogenesis imperfecta, who display some dentin defects and alveolar bone loss. we previously reported essential roles of bmp1 and tolloid-like 1 (tll1), two closely related extracellular proteinases with overlapping functions, in mouse periodontium growth by simultaneous knockout (ko) of both genes, although the separate roles of bmp1 and tll1 have remained unclear. here, we have investigated whether and how bmp1 and tll1 separately maintain periodontal homeostasis by comparing single bmp1 ko and tll1 ko with double ko (dko) phenotypes. ## Methods: Floxed bmp1 and/or tll1 alleles were deleted in transgenic mice via ubiquitously expressed cre induced by tamoxifen treatment starting at 4-weeks of age (harvested at 18-weeks of age). multiple approaches, including x-ray, micro-ct, calcein and alizarin red double-labeling, scanning electron microscopy, and histological and immunostaining assay

Who reads Proteinase Bone Morphogenetic Protein 1, but Not Tolloid‐like 1, Plays a Dominant Role in Maintaining Periodontal Homeostasis?

Author

Jun Wang; Xudong Xie; Nicole A. Muench; Dawiyat Massoudi; Chunmei Xu; Daniel S. Greenspan; Jian Q. Feng

Publisher

American Academy of Periodontology; Wiley (John Wiley & Sons); John Wiley and Sons Inc.; Wiley; American Academy of Periodontology (AAP) (ISSN 0022-3492)

Published

2020

Language

EN

Field

Dentistry (Health Sciences)