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Potent neutralizing anti-SARS-CoV-2 human antibodies cure infection with SARS-CoV-2 variants in hamster model 2 Introduction 2 Results 3 Identification and characterization of anti-SARS-CoV-2 antibodies from convalescent COVID-19 patients 3 Evaluation of in vitro efficacy against SARS-CoV-2 variants 4 Classification of mAb epitopes 5 Potent in vivo efficacy on different SARS-CoV-2 variants in the Syrian golden hamster model 6 Dose-dependent therapeutic efficacy of 3B8 8 Intramuscular delivery of DNA-based 3B8 8 Discussion 10 Limitations of the study 14 Supplemental information 15 Acknowledgments 15 Author contributions 15 Declaration of interests 15 References 15 STAR★Methods 18 Key resources table 18 Resource availability 19 Lead contact 19 Materials availability 19 Data and code availability 20 Experimental model and subject details 20 Human subjects 20 Animals 20 Cell lines 20 HEK293-F cells 20 HEK293-T cells 20 BHK-21J cells 20 Vero E6 cells 20 Viral strains 20 Method details 21 Isolation of PBMCs from convalescent COVID-19 patients 21 Single-cell sorting of antigen-specific B cells 21 Amplification of antibody variable domains 21 Recombinant antibody production and purificatio

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nonfiction