Can I read UTX is an escape from X-inactivation tumor-suppressor in B cell lymphoma on EtoBox?

UTX is an escape from X-inactivation tumor-suppressor in B cell lymphoma by Li, Xiaoxi; Zhang, Yanli; Zheng, Liting; Liu, Mingxian; Chen, Charlie Degui; Jiang, Hai is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is UTX is an escape from X-inactivation tumor-suppressor in B cell lymphoma about?

To explain the excess cancer rate in males, several candidates for “escape from X-inactivation tumor-suppressor” (EXITS) were recently identified. In this report we provide direct experimental evidence supporting UTX’s role as an EXITS gene. Using a mouse lymphoma model, we show clear dosage effect of UTX copy number during tumorigenesis, which strongly supports the EXITS theory. Importantly, UTX deletion not only accelerates lymphomagenesis, it also strongly promotes tumor progression. UTX-knockout tumors are more aggressive, showing enhanced brain dissemination and formation of blood vessels. Efnb1 is overexpressed in UTX KO tumors and can lead to such phenotypes. In human patients, lymphomas with low UTX expression also express high levels of Efnb1, and cause significantly poor survival. Lastly, we show that UTX deficiency renders lymphoma sensitive to cytarabine treatment. Taken together, these data highlight UTX loss’s profound impacts on tumor initiation and drug response.

Who reads UTX is an escape from X-inactivation tumor-suppressor in B cell lymphoma?

Author

Li, Xiaoxi; Zhang, Yanli; Zheng, Liting; Liu, Mingxian; Chen, Charlie Degui; Jiang, Hai

Publisher

Nature Publishing Group; Springer Science and Business Media LLC; [London]: Nature Publishing Group, 2010-; Society for Mining, Metallurgy and Exploration Inc.; Research Square (ISSN 2041-1723)

Published

2018

Language

EN

ISBN

9784146701809

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)