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Radioprotective Effects of Fucoidan in Mice Treated with Total Body Irradiation by Jeeyoung Lee; Jeongtae Kim; Changjong Moon; Sung-Ho Kim; Jin Won Hyun; Jae Woo Park; Taekyun Shin is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Radioprotective Effects of Fucoidan in Mice Treated with Total Body Irradiation about?
## Abstract The effects of fucoidan on the survival rate of mice treated with total body irradiation were examined. BALB/c mice were pretreated with various doses of fucoidan prior to total‐body irradiation and were monitored for 30 days. A significant improvement of survival was observed by pretreatment with fucoidan at 100 mg/kg body weight. Using this optimal dosage, survival was examined by radiation dose reduction analysis and a dose reduction factor (DRF) of 1.20 was determined at 30 days post‐irradiation. Mice pretreated with fucoidan also exhibited dose‐dependent increases in the number of bone marrow cells and endogenous spleen cell colonies at day 9 post‐irradiation. It is concluded that the increased survival of whole‐body irradiated mice pretreated with fucoidan may be attributable to the radioprotective effects of fucoidan on hematopoietic cell viability, proliferation and/or mobility, possibly through antioxidation or antiinflammatory mechanisms. Copyright © 2008 John Wiley & Sons, Ltd.
Who reads Radioprotective Effects of Fucoidan in Mice Treated with Total Body Irradiation?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Jeeyoung Lee; Jeongtae Kim; Changjong Moon; Sung-Ho Kim; Jin Won Hyun; Jae Woo Park; Taekyun Shin
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0951-418X)
- Published
- 2008
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)