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Gene structure of a major form of phenobarbital-inducible cytochrome P-450 in rat liver. by Y Suwa; Y Mizukami; K Sogawa; Y Fujii-Kuriyama is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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The gene structure of cytochrome P-450b, a major form of phenobarbital-inducible cytochrome P-450 in rat livers was elucidated by sequence analysis of the cloned genomic DNAs and was compared with the previously determined gene structures of cytochrome P-450e, a minor form of phenobarbital-inducible cytochrome P-450 and two forms of 3-methylcholanthrene-inducible cytochrome P-450 (P-45Oc and -d). The gene for cytochrome P-450b is 23 kilobase pairs (kb) long and is separated into 9 exons by 8 intervening sequences. This gene structure is very similar to that of cytochrome P-450e except for the first intron, the first intron being much longer in cytochrome P-450b gene (approximately 12 kb) than in cytochrome P-450e gene (3.2 kb), but differs greatly from the gene structures of two 3-methylcholanthrene-inducible cytochrome P-450s as pointed out previously (Sogawa, K., Gotoh, O., Kawajiri, K. & Fujii-Kuriyama, Y. (1984)

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Author

Y Suwa; Y Mizukami; K Sogawa; Y Fujii-Kuriyama

Publisher

Elsevier BV

Published

1985

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)