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Regulation of Aurora-A Kinase Gene Expression Via GABP Recruitment of TRAP220 by Ran Lin is a document available to read on EtoBox.
The study investigates the role of TRAP220/MED1 in regulating the expression of the Aurora-A kinase gene, which is crucial for cell growth and mitotic progression. It was found that TRAP220/MED1 is necessary for maintaining high levels of Aurora-A expression and is recruited to its promoter via the transcription factor GABP. The findings suggest that TRAP220/MED1 plays a significant coregulatory role in facilitating the recruitment of the TRAP/Mediator complex to specific target genes involved in cell growt
- Author
- Ran Lin
- Language
- EN