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Can I read Chiral cruciferous phytoalexins: Preparation, absolute configuration, and biological activity on EtoBox?
Chiral cruciferous phytoalexins: Preparation, absolute configuration, and biological activity by Kenji Monde; Tohru Taniguchi; Nobuaki Miura; Peter Kutschy; Zuzana Čurillová; Martina Pilátová; Ján Mojžiš is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Chiral cruciferous phytoalexins: Preparation, absolute configuration, and biological activity about?
Synthesized by an efficient one-pot spirocyclization method, two chiral cruciferous phytoalexins, 1-methoxyspirobrassinin (2) and 1-methoxyspirobrassinol methyl ether (4a), were prepared through optical resolution using the chiral HPLC method of corresponding racemates. The absolute configuration of natural (+)-2 was elucidated as R by using the direct comparison of ECD and VCD spectra with those of known (S)-(-)-spirobrassinin (1). Another chiral phytoalexin, (-)-4a, had its absolute configuration 2R,3R elucidated through the comparison of observed and calculated VCD. Interestingly, the absolute configurations of natural (S)-(-)-spirobrassinin (1) and (R)-(+)-1-methoxyspirobrassinin (2) were opposite of each other, even though their structures are almost similar, with the exception of an N-methoxy group. A significant difference in the antiproliferative activity between (2R,3R)-(-) and (2S,3S)-(+)-4a was observed.
Who reads Chiral cruciferous phytoalexins: Preparation, absolute configuration, and biological activity?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Kenji Monde; Tohru Taniguchi; Nobuaki Miura; Peter Kutschy; Zuzana Čurillová; Martina Pilátová; Ján Mojžiš
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0968-0896)
- Published
- 2005
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)