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The study presents a novel drug delivery system using Stattic-loaded mesoporous silica nanoparticles (PEG-MSN-Stattic) to target myeloid-derived suppressor cells (MDSCs) in tumors, enhancing the efficacy of immune checkpoint blockade (ICB) therapy. By reducing MDSC populations and increasing T lymphocyte infiltration, the PEG-MSN-Stattic system significantly improves antitumor responses and tumor growth inhibition. This approach offers a promising strategy for regulating the tumor microenvironment and boost
- Author
- bavisharaj17
- Language
- EN