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Choline Acetyltransferase Immunoreactivity in the Human Vestibular End-organs by Akira Ishiyama; Ivan Lopez; Phillip A. Wackym is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## ABSTRACT Acetylcholine (ACh) is believed to play a major role in the efferent vestibular system in several animal models, however no information regarding the role of ACh in the human efferent vestibular system has been published. Post‐embedding immunohistochemistry in a hydrophilic resin was used to investigate the choline acetyltransferase immunoreactivity (ChATi) and acetylcholinesterase (ACHE) histochemistry in human vestibular end‐organs. ChATi and AChE activity was found in numerous bouton‐type terminals at the basal area of the vestibular hair cells. These terminals were found to contact type II vestibular hair cells and the afferent chalices surrounding type I hair cells. This study provides the first evidence that the human efferent vestibular axons and terminals are cholinergic.

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Author

Akira Ishiyama; Ivan Lopez; Phillip A. Wackym

Publisher

Elsevier Science; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley (ISSN 1065-6995)

Published

1994

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)