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Hereditary hemochromatosis gene (HFE) variants are associated with birth weight and childhood leukemia risk by M. Tevfik Dorak; Rachel K. Mackay; Caroline L. Relton; Mark Worwood; Louise Parker; Andrew G. Hall is a Medicine article available to read on EtoBox.

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## Abstract ## Background Our original studies reported an association between the iron‐metabolism gene __HFE__ and risk of childhood acute lymphoblastic leukemia (ALL), and a birth weight association in ALL. Through its effect on cell proliferation, iron is involved in both fetal development and cancer. We hypothesize that __HFE__ links higher infant birth weight with leukemia risk and that maternal __HFE__ genotype modifies this association. ## Procedure Nine hundred ninety‐five infants and their mothers from the North Cumbria Community Genetics Project, and 163 incident childhood ALL cases from the Newcastle Haematology Biobank were genotyped for __HFE__, __HAMP__, __TFRC__ variants and 21 genomic control loci. Cord blood iron levels were measured in 217 control infants. ## Results Three __HFE__ variants showed correlations with birth weight with a gene–dosage relationship in males (gender effect). The association was stronger in homozygotes for __TFRC__ S142G and when the mother was positive for any __HFE__ variant (maternal effect). The genotypes expected to increase fetal iron levels correlated with birth weight in males and their association with ALL was stronger in females

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Author

M. Tevfik Dorak; Rachel K. Mackay; Caroline L. Relton; Mark Worwood; Louise Parker; Andrew G. Hall

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1545-5009)

Published

2009

Language

EN

Field

Medicine (Health Sciences)