Can I read Quantification of the α- and γ-Tocopherol Metabolites 2,5,7,8-Tetramethyl-2-(2′-carboxyethyl)-6-hydroxychroman and 2,7,8-Trimethyl-2-(2′-carboxyethyl)-6-hydroxychroman in Human Serum on EtoBox?

Quantification of the α- and γ-Tocopherol Metabolites 2,5,7,8-Tetramethyl-2-(2′-carboxyethyl)-6-hydroxychroman and 2,7,8-Trimethyl-2-(2′-carboxyethyl)-6-hydroxychroman in Human Serum by W. Stahl; P. Graf; R. Brigelius-Flohé; W. Wechter; H. Sies is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Quantification of the α- and γ-Tocopherol Metabolites 2,5,7,8-Tetramethyl-2-(2′-carboxyethyl)-6-hydroxychroman and 2,7,8-Trimethyl-2-(2′-carboxyethyl)-6-hydroxychroman in Human Serum about?

The metabolites are 2,5,7,8-tetramethyl-2-(2-carboxyethyl)-6-hydroxychroman (␣-CEHC) and 2,7,8-trimethyl-2-(2carboxyethyl)-6-hydroxychroman (␥-CEHC, LLU-␣), respectively. ␣-CEHC is excreted mainly as glucuronide or sulfate conjugates in the urine. Here we describe a sensitive and reliable method to analyze ␣and ␥-CEHC in human serum. The concentration of ␣-CEHC in human serum is in the range of 5-10 pmol/ml but increases significantly up to 200 pmol/ml upon supplementation with RRR-␣-tocopherol. About one-third of the ␣-CEHC circulating in the blood is present as a glucuronide conjugate. Baseline levels of ␥-CEHC are about 50 to 85 pmol/ml.

Who reads Quantification of the α- and γ-Tocopherol Metabolites 2,5,7,8-Tetramethyl-2-(2′-carboxyethyl)-6-hydroxychroman and 2,7,8-Trimethyl-2-(2′-carboxyethyl)-6-hydroxychroman in Human Serum?

Author

W. Stahl; P. Graf; R. Brigelius-Flohé; W. Wechter; H. Sies

Publisher

Elsevier Science; Elsevier ; Elsevier Inc.; Elsevier BV (ISSN 0003-2697)

Published

1999

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)