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Expression of Caspase‐3 and Structural Changes Associated with Apoptotic Cell Death of Keratinocytes in Oral Lichen Planus by SI Tobón‐Arroyave; FA Villegas‐Acosta; SM Ruiz‐Restrepo; B Vieco‐Durán; M Restrepo‐Misas; ML Londoño‐López is a Dentistry article available to read on EtoBox.

What is Expression of Caspase‐3 and Structural Changes Associated with Apoptotic Cell Death of Keratinocytes in Oral Lichen Planus about?

**Objective:** Apoptosis appears to be the mode of cell death by which damaged cells are removed from the lesional tissue. The aim of this study was to examine keratinocyte apoptosis and caspase‐3 (CPP32) expression in oral lichen planus (OLP). **Materials and methods:** Paraffin‐embedded samples of OLP (__n__ = 30) and normal oral mucosa (NOM; __n__ = 5) were prepared for haematoxylin–eosin (H & E), immunohistochemistry and electron microscopy. The number of apoptotic cells and the proportion of total cells that were either apoptotic (apoptotic index; AI) or mitotic (mitotic index; MI) were assessed in H & E stained sections. An immunostaining‐intensity‐distribution index (IIDI; proportion of stained cells × staining intensity) was used to assess CPP32 immunoreactivity. **Results:** Results showed a significant increase in the number of apoptotic cells in OLP (__P__ < 0.001). In OLP, all apoptotic bodies were found in the basal and prickle epithelial layers. Compared with NOM, the AI was significantly greater in atrophic (__P__ < 0.05), reticular (__P__ < 0.001) and plaque‐like (__P__ < 0.01) OLP. The MI was significantly greater in plaque‐like OLP (__P__ < 0.01). The proportion o

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Author

SI Tobón‐Arroyave; FA Villegas‐Acosta; SM Ruiz‐Restrepo; B Vieco‐Durán; M Restrepo‐Misas; ML Londoño‐López

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Wiley-Blackwell; Wiley (ISSN 1354-523X)

Published

2004

Language

EN

Field

Dentistry (Health Sciences)