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Regulation of biosynthesis and transport of aromatic amino acids in low-GC Gram-positive bacteria by Ekaterina M Panina; Alexey G Vitreschak; Andrey A Mironov; Mikhail S Gelfand is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Regulation of biosynthesis and transport of aromatic amino acids in low-GC Gram-positive bacteria about?

Computational comparative techniques were applied to analysis of the aromatic amino acid regulon in Gram-positive bacteria. A new candidate transcription regulation signal of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase and shikimate kinase genes was identified in Streptococcus and Lactococcus species. New T-boxes were found upstream of aromatic amino acid biosynthesis and transport genes in the Bacillus/Clostridium group. The substrate specificity of proteins from the PabA/TrpG family was assigned based on metabolic reconstruction and analysis of regulatory signals and phylogenetic patterns. New candidate tryptophan transporters were identified; their specificity was predicted by analysis of T-box regulatory sites. Comparison of all available genomes shows that regulation of genes of the aromatic amino acid biosynthesis pathway is quite labile and involves at least four regulatory systems, two at the DNA level and two more involving competition of alternative RNA secondary structures for transcription and/or translation regulation at the RNA level.

Who reads Regulation of biosynthesis and transport of aromatic amino acids in low-GC Gram-positive bacteria?

Author

Ekaterina M Panina; Alexey G Vitreschak; Andrey A Mironov; Mikhail S Gelfand

Publisher

John Wiley and Sons; Oxford University Press; Oxford University Press (OUP); Elsevier BV (ISSN 0378-1097)

Published

2003

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)