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Abstract | Over the past 15 years it has become clear that mutations in genes that regulate endocrine signalling pathways can prolong lifespan. Lifespan can be increased by altered endocrine signalling in a group of cells or a single tissue, which indicateage-related diseases. 12 Box 1 | Insulin/IGF1 signalling pathways in the regulation of ageing 13 The insulin/IGF1 pathway 13 Box 2 | Dauer formation mutants in the study of ageing 14 Figure 1 | Cell non-autonomous regulation of lifespan by insulin/insulin-like growth factor-1 signalling in worms. Insulin released from neurons activates DAF‐2 (abnormal dauer formation-2), which leads to the inhibition of DAF‐16 activity. Reducing the acSIR-2.1, sirtuin-2.1. 14 Control of lifespan by insulin in mammals 14 Figure 2 | Cell non-autonomous regulation of lifespan by insulin/IGF1 signalling in flies. Overexpression or activation of the class O forkhead box transcription factor FOXO localized to the fat body results in longevity. Diminished insulin signalling, ove 15 KLOTHO, an anti-ageing hormone? 16 Figure 3 | Regulation of lifespan by insulin/IGF1 signalling in mice. Inhibition of insulin-like growth factor-1 (IGF1) signalling (by IGF1

Who reads Nature Reviews Molecular Cell Biology 2007 No 9?

Publisher

Nature Publishing Group

Published

2007

Language

EN

Category

magazine