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Trans Fat Intake During Pregnancy or Lactation Increases Anxiety-like Behavior and Alters Proinflammatory Cytokines and Glucocorticoid Receptor Levels in the Hippocampus of Adult Offspring by Camila Simonetti Pase; Vinícia Garzella Metz; Karine Roversi; Katiane Roversi; Luciana Taschetto Vey; Verônica Tironi Dias; Carolina Fouchy Schons; Caren Tatiane de David Antoniazzi; Thiago Duarte; Marta Duarte; Marilise Escobar Burger is a Neuroscience article available to read on EtoBox.

What is Trans Fat Intake During Pregnancy or Lactation Increases Anxiety-like Behavior and Alters Proinflammatory Cytokines and Glucocorticoid Receptor Levels in the Hippocampus of Adult Offspring about?

Changes in dietary habits, including the increased consumption of processed foods, rich in trans fatty acids (TFA), have profound effects on offspring health in later life. Thus, this study aimed to assess the influence of maternal trans fat intake during pregnancy or lactation on anxiety behavior, as well as markers of inflammation, oxidative stress, and expression of glucocorticoid receptors (GR) of adult male offspring. Female Wistar rats were supplemented daily with soybean oil/fish oil (SO/FO) or hydrogenated vegetable fat (HVF) by oral gavage (3.0 g/kg body weight) during pregnancy or lactation. After weaning, male offspring received only standard diet. On the postnatal day 60, anxiety-like symptoms were assessed, the plasma was collected for the quantification of cytokines levels and the hippocampus removed for biochemical and molecular analysis. Our findings have evidenced that offspring from HVF-supplemented dams during pregnancy or lactation showed significantly greater levels of anxiety behavior. HVF supplementation increased plasma levels of proinflammatory cytokines and these levels were higher in the lactation period. In contrast, HVF supplementation decreased plasma

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Author

Camila Simonetti Pase; Vinícia Garzella Metz; Karine Roversi; Katiane Roversi; Luciana Taschetto Vey; Verônica Tironi Dias; Carolina Fouchy Schons; Caren Tatiane de David Antoniazzi; Thiago Duarte; Marta Duarte; Marilise Escobar Burger

Published

2020

Language

EN

Field

Neuroscience (Life Sciences)